Pragmatic, adaptive clinical trials: Is 2020 the dawning of a new age?

Given the high case fatality rate of SARS-CoV-2, for which there is telemarkskongen flue no cure and no vaccine, clinicians are forced to make decisions about how best to manage patients with limited high-quality evidence to guide treatment.Traditional randomized controlled trials provide strong experimental evidence, however, tend to be equi-jec 6 slow, inflexible, and have limited generalizability.Adaptive and pragmatic designs are an attractive alternative, which meet our ethical obligation during the SARS-CoV-2 pandemic to balance speed, agility, and generalizability with both prospective study and scientific rigor.